The Influence of Hydrogen Ion Concentration on the Inactivation of Pepsin Solutions

Native and Unfolded States of Pepsinogen. Ii. the Kinetics of the Structural Transition Induced by Urea.

In the preceding communication, the molecular properties of pepsinogen in water and water-urea solutions were evaluated (1). In this report the rates of unfolding of pepsinogen as a function of pH and temperature in urea solutions are presented. A comparison can then be made between the influence of these variables on pepsinogen denaturation and the results of a similar study reported several y...

The Effect of Various Acids on the Digestion of Proteins by Pepsin

1. At equal hydrogen ion concentration the rate of pepsin digestion of gelatin, egg albumin, blood albumin, casein, and edestin is the same in solutions of hydrochloric, nitric, sulfuric, oxalic, citric, and phosphoric acids. Acetic acid diminishes the rate of digestion of all the proteins except gelatin. 2. There is no evidence of antagonistic salt action in the effect of acids on the pepsin d...

The Enzymatic Synthesis of Protein. Iii. the Effect of the Hydrogen Ion Concentration on Peptic Synthesis. by Hardolph

In two previous communications the authors have described a synthesis of protein by pepsin in a concentrated peptic hydrolysate of albumin (1) ; and the effect of temperature on this synthesir (2). The justification for describing the synthetic product as protein is discussed in our previous paper (2). In these communications the optimum hydrogen ion concentration was stated to be pH 4.0; but t...

The effect of hydrogen ion concentration on the anatomy of tobacco

The Significance of the Hydrogen Ion Concentration for the Digestion of Proteins by Pepsin

The experiments described above show that the rate of digestion and the conductivity of protein solutions are very closely parallel. If the isoelectric point of a protein is at a lower hydrogen ion concentration than that of another, the conductivity and also the rate of digestion of the first protein extends further to the alkaline side. The optimum hydrogen ion concentration for the rate of d...